Step 1

Choose CYP2D6 Alleles

Alleles listed have a defined CPIC function, current as of 5/10/2023

Allele 1 Please select... *1 *2 *3 *4 *5 *6 *7 *8 *9 *10 *11 *12 *13 *14 *15 *17 *18 *19 *20 *21 *27 *29 *31 *32 *33 *34 *35 *36 *38 *39 *40 *41 *42 *44 *45 *46 *47 *48 *49 *50 *51 *52 *53 *54 *55 *56 *57 *59 *60 *62 *68 *69 *72 *81 *84 *91 *92 *96 *99 *100 *101 *109 *114 *120 *124 *129 *119 *132 *143 *144 *156 *161 Allele 2 Please select... *1 *2 *3 *4 *5 *6 *7 *8 *9 *10 *11 *12 *13 *14 *15 *17 *18 *19 *20 *21 *27 *29 *31 *32 *33 *34 *35 *36 *38 *39 *40 *41 *42 *44 *45 *46 *47 *48 *49 *50 *51 *52 *53 *54 *55 *56 *57 *59 *60 *62 *68 *69 *72 *81 *84 *91 *92 *96 *99 *100 *101 *109 *114 *120 *124 *129 *119 *132 *143 *144 *156 *161

Is there an extra allele present?

Does this individual have a copy number variation present?

Yes
No

How many total alleles?

If your lab cannot detect the number of alleles present, choose "Unknown". If you know the exact number, choose "3" or "4" as appropriate. If the individual has >4, choose "≥5". If individual has 2, then no extra alleles are present and “No” should be selected on previous question.

Unknown
3
4
≥5

Choose CYP2C19 Alleles

Alleles listed have a defined CPIC function, current as of 2/1/2020

Allele 1 Please select... *1 *2 *3 *4 *5 *6 *7 *8 *9 *10 *11 *13 *15 *16 *17 *18 *19 *22 *24 *25 *26 *28 *35 *36 *37 Allele 2 Please select... *1 *2 *3 *4 *5 *6 *7 *8 *9 *10 *11 *13 *15 *16 *17 *18 *19 *22 *24 *25 *26 *28 *35 *36 *37

Genotype-based CYP2D6 Activity Score

This is the individual’s CYP2D6 activity score, which is based on genotype alone.

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Genotype-based CYP2D6 Phenotype

This is the individual’s predicted CYP2D6 phenotype, which is based on their “Genotype-based CYP2D6 Activity Score”. It is possible a range phenotype is predicted as the individual’s exact phenotype cannot be determined.

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Step 3

Assess Oral Concomitant Medications

Is the patient taking one or more of the CYP2D6 inhibitors below? Check all that apply.

Abiraterone (Zytiga®)
Bupropion (Wellbutrin®)
Cinacalcet (Sensipar®)
Duloxetine (Cymbalta®)
Fluoxetine (Prozac®)
Mirabegron (Myrbetriq®)
Paroxetine (Paxil®)
Quinidine (Quinidex®)
Terbinafine (Lamisil®)
No Inhibitor Present

Adjusted CYP2D6 Activity Score

This is the individual’s adjusted CYP2D6 activity score, which is based on genotype AND CYP2D6 inhibitors (drug interactions).

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Clinical CYP2D6 Phenotype

This is the individual’s predicted clinical phenotype, which is based on adjusted CYP2D6 activity score.
Activity scores are translated to phenotype as follows:
Activity score 0: Poor Metabolizer
Activity Score >0 - 0.75: Intermediate Metabolizer
Activity Score >0.75 – 2: Normal Metabolizer
Activity Score >2: Ultrarapid Metabolizer

Genotype-based CYP2C19 Phenotype

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Treatment Recommendation

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Disclaimer

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